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by Paul Muaddib - republished with permission from Qplusnews

“Chloroquine is a 9-aminoquinoline known since 1934.”

Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses.”

“This old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.”

 covid1a

“Based on the effects of chloroquine/hydroxychloroquine on several enveloped viruses and on immune activation, we raise the hypothesis that this drug might be of some use for the clinical management of SARS.”

 covid2

“Preliminary data obtained from our group confirm these reports and show that chloroquine potently inhibits the replication of a canine coronavirus at therapeutically reachable concentrations.”

 sars1

“The causative agent of SARS has recently been described as a new coronavirus.  Recent studies support the idea that coronaviridae infect their target cells by an endocytic pathway and that chloroquine might inhibit their replication.”

 vid1

“Chloroquine/Hydroxychloroquine, due to its antiviral and anti-inflammatory properties, may have some effect on SARS. We emphasise the need of testing in cell cultures infected with SARS coronavirus the effects of chloroquine, as well as those of other substances possessing in-vitro activity against members of the coronaviridae family.”

“SARS coronavirus, the possibility of an inhibition, at least in vitro, of the replication of this virus would represent a breakthrough in the knowledge of SARS.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128816/

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